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g-Secretase mediated ErbB4 Signaling Pathway
来自 : 发布时间:2025-01-15

TheHER4/erbB4receptortyrosinekinaseisamemberoftheEGF1receptorfamily.HER4isareceptorfortheneuregulins(NRGs),afamilyofgrowthanddifferentiationfactors.HER4canalsobindandbeactivatedbyheparin-bindingEGFgrowthfactor,betacellulin,andepiregulin,membersoftheEGFfamilywhich,unliketheNRGs,arealsoligandsfortheEGFreceptor.HER4mRNAisexpressedinseveraltissuessuchasheart,brain,kidney,andskeletalmuscle,suggestingthatthisreceptorisinvolvedinthedevelopmentandmaintenanceofavarietyoforgansandcelltypes.ItislikelythatthecontrolofexpressionandfunctionofHER4isimportantinnormaldevelopmentaswellasindisease.

Contributor:

REFERENCES:Ni,C.-Y.,Murphy,M.P.,Golde,T.E.,Carpenter,G.(2001).gamma-SecretaseCleavageandNuclearLocalizationofErbB-4ReceptorTyrosineKinase.Science294:2179-2181RioC,BuxbaumJD,PeschonJJ,CorfasG.Tumornecrosisfactor-alpha-convertingenzymeisrequiredforcleavageoferbB4/HER4.JBiolChem2000Apr7;275(14):10379-87

本文链接: http://simport.immuno-online.com/view-1545760038.html

发布于 : 2025-01-15 阅读()